The Effectiveness of Fluconazole 150 mg against Fungal Infections

Posted By on February 3, 2016

Fluconazole is a well-known medicine that can combat infections caused by fungi. It can be given to the patient via oral route (orally) or via the vein (intravenous).  Fluconazole is very helpful in many cases associated with various kinds of fungal infections, most especially the infections located at the vagina (the so-called vaginal yeast infections), throat, bloodstream and mouth caused by Candida species.

Fluconazole was originally developed by Pfizer scientists and it was initially distributed to the public in the year 1990. These days, fortunately, fluconazole is available worldwide as an affordable generic drug.  Fluconazole is a drug that it has been listed by the World Health Organization as a very essential one, which has to be present at all times in order to maintain a healthy community.

Fluconazole 150 mg is a first-generation triazole drug that is very effective in cases of the following fungal-caused infections below:

  • Coccidioidomycosis – The recommended dosages range from 200 mg up to 400 mg, for a period of 11 months up to 2 years or even longer, depending on the patient’s tolerance, improvement and other factors.
  • Mucosal candidiasis such as candiduria , esophageal and oropharyngeal candidiasis as well as chronic mucocutaneous candidiasis. For chronic mucocutaneous candidiasis, the doctor will recommend fluconazole 150 mg every day, to be taken for 28 days, or longer if the severity of the condition persists and if the patient is still very immune compromised from the infection.
  • Chronic oral atrophic candidiasis (denture sore mouth) if dental hygiene or topical treatment are insufficient.
  • Acute or recurrent vaginal candidiasis – a single dose of fluconazole 150 mg must be given. For treatment and prevention of vaginal candidiasis (around 4 or more instances per year), the patient has to be given fluconazole 150 mg every 3rd day for a total of 3 times (days 1, 4, 7), subsequently followed by fluconazole 150 mg once a week as maintenance.  The maintenance dose of fluconazole 150 mg must be carried out for a full 6 months.
  • Candidal balanitis – a single dose of fluconazole 150 mg must be given.
  • Dermatomycosis such as tinea corporis, tinea pedis, tinea cruris and skin-related candida infections when therapy of systemic means is required, administration of fluconazole 150 mg once a week or 50 mg once every day is necessary. Most of the dermatomycosis problems need to be treated for a period of 2 to 4 weeks, whereas for cases of tinea pedis, the treatment with fluconazole 150 mg should be for a period of up to 6 weeks.
  • Cryptococcal meningitis – The day 1 dose is actually 400 mg, and the next doses can be 200 mg up to 400 mg every day, for a period of 6 to 8 weeks. There is actually very little evidence noted when it comes to the effectiveness of fluconazole 150 mg in the case of cryptococcosis infections in other body areas such as cutaneous and pulmonary cryptococcosis; therefore, the dosing recommendations of fluconazole 150 mg is somewhat limited.

Should you be allergic to fluconazole, or if you are taking cisapride, astemizole, ergotamine, pimozide, terfenadine, voriconazole, or quinidine, then you must not take any fluconazole in the first place and ask your doctor for an alternative.

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